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Sulfates are the main circulating conjugates of ethinyl estradiol and glucuronides predominate in urine. The key oxidative metabolite is 2-hydroxy ethinyl estradiol, shaped through the CYP3A4 isoform of cytochrome P450. Part of the initial-go metabolism of ethinyl estradiol is considered to manifest in gastrointestinal mucosa. Ethinyl estradiol may